A recent study led by Gregory Luke Smith presents groundbreaking findings in the field of hair regrowth, utilizing a specific hemp extract enriched with cannabinoids. Published in the International Journal of Trichology, this research explores the potential of cannabidiol (CBD), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV) in treating androgenetic alopecia (AGA).
The Role of the Endocannabinoid System
The endocannabinoid system, a complex cellular signaling network discovered in the 1990s, plays a critical role in maintaining cellular homeostasis, regulating inflammatory responses, and promoting regenerative processes. Smith’s study focuses on the unique therapeutic effects of these cannabinoids on hair regrowth, mediated through this system, representing a novel approach compared to traditional treatments.
Study Methodology and Objectives
The case series involved 31 subjects with AGA, who applied a topical hemp extract formulation daily for six months. Participants, including men and women of various ethnicities, demonstrated an average hair count increase of 246% for men and 127% for women. The study aimed to assess whether daily application of hemp oil high in CBD, THCV, and CBDV could enhance hair regrowth in affected scalp areas.
Remarkable Results and Observations
The findings were striking, with all subjects experiencing some level of hair regrowth, ranging from 31.25% to an astounding 2000%. The average increase was statistically significant, and no adverse effects were reported. Moreover, participants noted a positive psychosocial perception of the hair regrowth effects, expressing happiness and satisfaction. Independent before-and-after photo examinations corroborated these claims.
Conclusions and Future Implications
While the exact therapeutic mechanisms remain partially understood, the study suggests that THCV and CBDV likely act as neutral antagonists of the CB1 receptor, with CBD as a partial antagonist, potentially through the Wnt signaling pathway. This innovative research paves the way for further exploration into combining hemp extract with conventional hair regrowth therapies, showing promise as a complementary treatment option.